Overview
PIs: Dr. Josep Bassaganya-Riera and Dr. Raquel Hontecillas
Sponsor: NIH/NIAID IDIQ
Award size: $40M
Award duration: 7 years
Contract number: HHSN272201700042I
Goals
1. Preclinical pig models of Helicobacter pylori infection (Develop, refine and use)
2. Computational models of enteric pathogen infection (Develop, refine and validate).
3. Therapeutics, vaccines and diagnostics in pigs and computational models of gastroenteric infection.
4. Develop an integrated data and metadata management system for data sharing across APMEP.
Overview
PIs: Dr. Josep Bassaganya-Riera and Dr. Raquel Hontecillas
Sponsor: Defense Threat Reduction Agency (DTRA)
Award size: $1.7M
Award duration: 5 years
Contract number: HDTRA1-18-1-0008
Goals
1. Develop a computational model of Clostridium difficile infection (CDI)
2. Develop a model of metabolic adaptation to CDI
3. Perform in silico studies in mice and humans infected C. difficile
4. Translate the CDI model to infection with Bacillus anthracis and other select agents
