Pharmacological activation of LANCL receptors has three-fold benefit in metabolic dysfunction-associated steatohepatitis

The LANCL family of receptors includes LANCL2, a membrane receptor associated with glycemic control and regulatory immune responses, [...]

Pharmacological activation of LANCL2 provides immunometabolic support for the restoration of cognitive function markers in a mouse model of Alzheimer’s disease

LANCL2 is a member of a three-protein family of receptors that acts as the mammalian receptor for abscisic acid (ABA). LANCL2 [...]

Pharmacological activation of LANCL2 ameliorates disease severity and decreases inflammation in a preclinical model of rheumatoid arthritis

Abstract. Lanthionine synthetase C-like 2 (LANCL2) is a novel immunoregulatory therapeutic target for the treatment of autoimmune [...]

Lanthionine synthetase C-like receptors reduce eosinophilia, type 2 immune responses and lung inflammatory pathology in mouse models of asthma

Airway hyperresponsiveness and asthma are associated with altered glucose metabolism with inhibition of anaerobic glycolysis reducing [...]

Safety and Tolerability of NIM-1324, an Oral, Once-daily LANCL2 Agonist, in a Randomized, Double-Blind, Placebo-Controlled Phase 1 Study in Normal Healthy Volunteers

Background. Systemic lupus erythematosus is a complex disease in which the immune system is dysfunctional at multiple levels including [...]

Efficacy and Safety of Omilancor in a Phase 2 Randomized, Double-blind, Placebo-controlled Trial of Patients with Crohn’s Disease

Introduction. Omilancor is an oral, gut-restricted, first-in-class LANCL2 agonist for ulcerative colitis (UC) and Crohn’s disease [...]

Transcriptional Analysis of Colonic Biopsies from Patients with Ulcerative Colitis Treated with Omilancor

Introduction. Omilancor is an oral, gut-restricted, first-in-class LANCL2 agonist for ulcerative colitis (UC) and Crohn’s disease [...]

Efficacy and Safety of Omilancor in a Phase 2 Randomized, Double-blind, Placebo-controlled Trial of Patients with Ulcerative Colitis

Introduction. Omilancor is an oral, gut-restricted, small molecule, first-in-class LANCL2 agonist for ulcerative colitis (UC) and [...]

Role of CD64+CX3CR1+ mononuclear phagocytes during Helicobacter pylori infection

Kronsteiner-Dobramysl, B., M. Viladomiu, J. Bassaganya-Riera, C. Phillipson, and R. Hontecillas, (2015) European Congress of [...]

The immune modulatory mechanisms of lanthionine synthetase C-like 2

Philipson, C., C. Hetzel, K. Eden, R. Hontecillas and J. Bassaganya-Riera (2015) The immune modulatory mechanisms of lanthionine [...]

Using Big Data to Inform Mental Health Policies

Andalib, M., G. Hughes, N. Hosseinichimeh, A.B. Lakeh, V. Abedi, R. Zand, N. Ghaffarzadegan. INFORMS 2015. Philadelphia, PA. November 1-4, 2015

ENISI Multiscale modeling of mucosal immune responses driven by high performance computing

Vida Abedi, Raquel Hontecillas, Stefan Hoops, Nathan Liles, Adria Carbo, Pinyi Lu, Cassandra Philipson and Josep Bassaganya-Riera. IEEE International Conference on Bioinformatics and Biomedicine (BIBM 2015). Washington, DC, USA. 2015

Modeling Immunity to Enteric Pathogens

Bassaganya-Riera, J. (2015) Invited Speaker; Modeling Immunity to Enteric Pathogens, Modeling Immunity for Biodefense Summer School/Symposia, Rochester, NY

Modeling Immune responses to Helicobacter pylori

Bassaganya-Riera, J. (2015) Invited Speaker; Modeling Immune responses to Helicobacter pylori, Modeling Immunity for Biodefense, Rockville, MD

Computational modeling of mechanisms underlying immune responses to Helicobacter pylori

Bassaganya-Riera, J. (2015) Invited Speaker; Computational modeling of mechanisms underlying immune responses to Helicobacter pylori, AMS Esteren Sectional, Georgetown University, Washington, DC

Computational immunology in autoimmune diseases

Bassaganya-Riera, J. (2014) Invited Speaker; Computational immunology in autoimmune diseases, Feinstein Institute for Medical Research, Manhasset, NY

ENISI MSM: A novel multiscale modeling platform

Bassaganya-Riera, J. (2014) Invited Speaker; ENISI MSM: A novel multiscale modeling platform, IEEE International Conference: BIBM, Belfast, UK

Multiscale Modeling and Computational Immunology in Infectious Diseases

Bassaganya-Riera, J. (2014) Invited Speaker; Multiscale Modeling and Computational Immunology in Infectious Diseases, DoD, Dahlgren, VA

Mechanisms underlying immune responses to enteric pathogens

Bassaganya-Riera, J. (2013) Invited speaker; Mechanisms underlying immune responses to enteric pathogens, Division of Gastroenterology, VT Carilion School of Medicine, Roanoke, VA.

From the past to the future

Bassaganya-Riera, J. (2013) Session Chair; International Conference on Computational Biology: From the past to the future, Virginia Tech, Blacksburg, VA.

The M2 Pipeline: A Novel Tool for Rapidly Analyzing Host Metabolic Profiles from RNA-seq Data

Abstract— A novel bioinformatics and data analytics pipeline that utilizes global gene expression datasets in combination with [...]