Pilot study of the effect of conjugated linoleic acid on the modulation of immune responses in patients with mild to moderately active Crohn’s disease

Isaacs, K.L., R. Hontecillas, W.T. Horne, M. Sandridge, H. Herfarth and J. Bassaganya-Riera (2011) Pilot study of the effect of conjugated linoleic acid on the modulation of immune responses in patients with mild to moderately active Crohn’s disease, American College of Gastroenterology Annual Meeting, Washington DC. Awarded American College of Gastroenterology Presidential Poster of distinction.

Dietary conjugated linoleic acid (CLA) has demonstrated efficacy as an immune modulator and anti-inflammatory compound in mouse and pig models of colitis. The anti-inflammatory effects of CLA in mice are mediated through a mechanism dependent on activation of peroxisome proliferator-activated receptor gamma. A pilot study was designed to investigate the effects of CLA modulation of the inflammatory response in patients with mild to moderate Crohn’s disease.